Serum and salivary oxidative analysis in Complex Regional Pain Syndrome

 

 

Serum and salivary oxidative analysis in Complex RegionalPain Syndrome

Serum and salivary oxidative analysis in Complex RegionalPain SyndromeElon Eisenberga,e, Shalom Shtahlb,e, Rimma Gellera, Abraham Z. Reznickc,e,Ordi Sharfa,b,e, Meirav Ravbinovicha,b, Adam Erenreicha,b, Rafael M. Naglerd,e,*aPain Relief Unit, Rambam Medical Center, Haifa, IsraelbDepartment of Hand Surgery, Rambam Medical Center, Haifa, IsraelcDepartment of Anatomy and Cell Biology, Rambam Medical Center, Haifa, IsraeldOral and Maxillofacial Surgery Department and Oral Biochemistry Laboratory, Rambam Medical Center, Bat Galim, 31096 Haifa, IsraeleBruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, IsraelReceived 13 November 2007; received in revised form 9 April 2008; accepted 15 April 2008
Abstract

Although both inflammatory and neural mechanisms have been suggested as potential contributors to Complex Regional PainSyndrome type I (CRPS-I), the pathogenesis of the syndrome is still unclear. Clinical trials have shown that free radical scavengerscan reduce signs and symptoms of CRPS-I, indirectly suggesting that free radicals and increased oxidative stress are involved in thepathogenesis of CRPS-I. This study investigated this premise by determining the levels of antioxidants in the serum and saliva of 31patients with CRPS-I and in a control group of 21 healthy volunteers. Serum lipid peroxidation products (MDA) and all antioxidative parameters analyzed were significantly elevated in CRPS-I patients: median salivary peroxidase and superoxide dismutase(SOD) activity values, uric acid (UA) concentration and total antioxidant status (TAS) values were higher in CRPS-I patientsby 150% (p = 0.01), 280% (p = 0.04), 60% (p = 0.0001), and 200% (p = 0.0003), respectively, as compared with controls. Similar although not as extensive pattern of oxidative changes were found in the serum: mean serum UA and MDA concentrations andTAS value in the CRPS-I patients were higher by 16% (p = 0.04), 25% (p = 0.02), and 22% (p = 0.05), respectively, than in the controls. Additionally, median salivary albumin concentration and median salivary LDH activities in the patients were 2.5 times(p = 0.001) and 3.1 (p = 0.004) times higher than in the controls. The accumulated data show that free radicals are involved inthe pathophysiology of CRPS-I, which is reflected both in serum and salivary analyses. These data could be used for both diagnosticand therapeutic purposes in CRPS-I patients. 2008 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

Keywords: Complex Regional Pain Syndrome type I (CRPS-I); Neuropathic pain; Inflammation; Ischemia; Oxidative stress; Antioxidants; Freeradical

 

 

Click here for the full report/original post of this report online.

 

.

 

 

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s