Complex regional pain syndrome 1 – the Swiss cohort study

Study protocol

Complex regional pain syndrome 1 – the Swiss cohort study

Florian Brunner email, Lucas M Bachmann email, Ulrich Weber email, Alfons GH Kessels email, Roberto SGM Perez email, Johan Marinus email and Rudolf Kissling email

BMC Musculoskeletal Disorders 2008, 9:92doi:10.1186/1471-2474-9-92

Published: 23 June 2008

Abstract (provisional)


Little is known about the course of Complex Regional Pain Syndrome 1 and potential factors influencing the course of this disorder over time. The goal of this study is a) to set up a database with patients suffering from suspected CRPS 1 in an initial stadium, b) to perform investigations on epidemiology, diagnosis, prognosis, and socioeconomics within the database and c) to develop a prognostic risk assessment tool for patients with CRPS 1 taking into account symptomatology and specific therapies.


Prospective cohort study. Patients suffering from a painful swelling of the hand or foot which appeared within 8 weeks after a trauma or a surgery and which cannot be explained by conditions that would otherwise account for the degree of pain and dysfunction will be included. In accordance with the recommendations of International Classification of Functioning, Disability and Health (ICF model), standardised and validated questionnaires will be used. Patients will be monitored over a period of 2 years at 6 scheduled visits (0 and 6 weeks, 3, 6, 12, and 24 months). Each visit involves a physical examination, registration of therapeutic interventions, and completion of the various study questionnaires. Outcomes involve changes in health status, quality of life and costs/utility.


This paper describes the rationale and design of patients with CRPS 1. Ideally, potential risk factors may be identified at an early stage in order to initiate an early and adequate treatment in patients with increased risk for delayed recovery.

Click Here For The Original Article Online.

Click Here for the full study (PDF)



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